Košice Region (Slovak: Košický kraj) is one of the eight Slovak administrative regions. It consists of 11 districts (okresy) and 440 municipalities, 17 of which have a town status. About one third of the region's population lives in the agglomeration of Košice, which is its main economic and cultural centre.

It is located in the southern part of eastern Slovakia and covers an area of 6,752 km2. The western part of the region is composed of the eastern part of the Slovak Ore Mountains. As for administrative divisions, the region borders Prešov Region in the north, Zakarpattia Oblast of Ukraine in the east, Szabolcs-Szatmár-Bereg and Borsod-Abaúj-Zemplén counties of Hungary in the south and the Banská Bystrica Region in the west.

The largest towns are Košice, Michalovce, Spišská Nová Ves, Trebišov and Rožňava. According to the 2001 census, there were 766,012 inhabitants in the region, with a majority of Slovaks (81.8%), but there is a numerous Hungarian minority (11.2%) in the south, and there are minorities of Roma (3.9%) and Czechs (<1%).

The economy of the Košice region accounted for 11.47% of Slovakia's GDP in 2013, which made it the region with the second highest GDP in Slovakia after the Bratislava region.

Košice Region was part of the Programme area of the Hungary-Slovakia-Romania-Ukraine ENPI CBC Programme 2007-2013. For CBC projects implemented by the lead partners and partners from Košice Region please check the KEEP database